2008-02-21 (BB): Updated the sham control role classes. Jeff Grethe Using birnlex IDs starting with 11000. Carol Bean The BIRN Project lexicon uses this file as a temporary proxy for classes from the Ontology of Biomedical Investigation (OBI). These classes will be replaced by their OBI equivalents, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. BIRNLex-OBI-proxy 2008-02-21 Amarnath Gupta The BIRN Ontology Task Force Christine Fennema-Notestine en next ID: birnlex_11049 Jessica Turner David Kennedy 2007-10-05 Bill Bug Maryann Martone 1.3.1 ID use: 11000 - 11048 The BIRN project lexicon Detector role http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_323 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 2007-10-05 Detector role This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Source code OBI_0000039 Source code We need to have this in there somewhere, but it looks like OBI has something equivalent "source code module"; they have it classified as an information content entity, so I placed it here. (Maryann Martone) OBI A source code module is an information content entity that specifies, using a programming language, some algorithm. December 15, 2008 http://obi.sourceforge.net/ontology/OBI.owl#OBI_295 Non-realizable information entity http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Non-realizable information entity http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 Reagent role 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_328 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. _1_3.2 Reagent role http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Entity of organismal origin Entity of organismal origin _1_3.5 In vitro anatomical object March 15, 2010 Ex vivo anatomical object http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://obi.sourceforge.net/ontology/OBI.owl#OBI_133 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://www.ifomis.org/bfo/1.1/snap#Object Microarray platform This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_52 2007-10-05 Microarray platform http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 _7_5.1 Placebo treatment This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2008-02-21 2008-02-21 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Placebo treatment http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://obi.sourceforge.net/ontology/OBI.owl#Placebo_treatment Cardinal part of instrument http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Cardinal part of instrument http://obi.sourceforge.net/ontology/OBI.owl#OBI_36 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_275 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 Journal article Journal article Publication A written composition, usually nonfiction, on a specific topic, forming an independent part of a journal or other publication. http://obi.sourceforge.net/ontology/OBI.owl#OBI_300 _7_12 2007-10-05 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Narrative object http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Narrative object http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Journal article resource Investigation administration role http://obi.sourceforge.net/ontology/OBI.owl#OBI_176 2007-10-05 Investigation administration role http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary December 15, 2008 software resource Binary executable is a digital entity consisting of the binary representation of machine instructions of a specific processor or they may be binary pseudocode for a virtual machine. A non-source executable file is also called an object program. It is assumed that the binary executable file contains properly-formatted computer instructions. (derived from Wikipedia, Nov 1, 2007) software program Software application http://obi.sourceforge.net/ontology/OBI.owl#OBI_351 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Software application OBI_0000222 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary _1_2 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Binary executable 2007-10-05 program http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Note _4_6.3 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Comment 2007-10-10 _7_12 Comment 2007-10-10 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_272 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Protocol Protocol This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 Definition and defining source has been added. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Algorithm December 15, 2008 2007-10-05 An algorithm is a plan which describes inputs, output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata. http://obi.sourceforge.net/ontology/OBI.owl#OBI_270 OBI Algorithm http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 Information entity http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_344 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Information entity 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Planned process http://obi.sourceforge.net/ontology/OBI.owl#OBI_600062 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Planned process http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 Assay 2007-10-05 Assay http://obi.sourceforge.net/ontology/OBI.owl#OBI_70 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 2007-10-05 _7_12.1 http://obi.sourceforge.net/ontology/OBI.owl#OBI_286 Clinical finding http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Clinical finding http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://obi.sourceforge.net/ontology/OBI.owl#OBI_147 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Quantitative value Quantitative value 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_94 Material transformation 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Material transformation 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2008-02-21 Sham treatment 2008-02-21 A subject group treatment identical to the experimental treatment but without the active agent under study. Sham treatment http://obi.sourceforge.net/ontology/OBI.owl#Sham_treatment http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2008-02-21 Reference Reference http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2008-02-21 http://obi.sourceforge.net/ontology/OBI.owl#Reference This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2008-02-21 Role in protocol application http://obi.sourceforge.net/ontology/OBI.owl#OBI_343 Role in protocol application http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug March 31, 2010 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_400003 Any entity used to perform a measurement, e.g., a microscope, a test battery This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Instrument _1_3.1 Instrument http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Imaging assay 2007-10-05 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Imaging assay http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_185 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://obi.sourceforge.net/ontology/OBI.owl#OBI_342 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Information content entity Information content entity 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_50 2007-10-05 2007-10-05 Platform This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Platform http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2008-02-21 http://ontology.neuinfo.org/NIF/Backend/BIRNLex-OBI-proxy.owl#birnlex_11017 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex-OBI-proxy.owl#birnlex_11045 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://obi.sourceforge.net/ontology/OBI.owl#OBI_173 Negative control role Negative control role 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_51 2007-10-05 Liquid chromatography mass spectrometry platform This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Liquid chromatography mass spectrometry platform http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2008-02-21 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Mock surgery http://obi.sourceforge.net/ontology/OBI.owl#Mock_surgery 2008-02-21 Sham surgery Mock surgery 2007-10-05 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. manufactured_object Artefact object Artefact entity http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary artefact object http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://obi.sourceforge.net/ontology/OBI.owl#OBI_47 2007-10-05 2007-10-05 Disease _8.3 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_155 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Disease Value This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_18 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://obi.sourceforge.net/ontology/OBI.owl#OBI_305 Data object Data object 2007-10-05 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Value 2007-10-05 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Reporter role 2007-10-05 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Reporter role http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://obi.sourceforge.net/ontology/OBI.owl#OBI_289 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Digital entity 2007-10-05 December 15, 2008 2007-10-05 OBI_0000261 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://obi.sourceforge.net/ontology/OBI.owl#OBI_306 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug A digital entity is an information entity which is a collection of bits that can be interpreted by a computer. Two digital entities are the same if they are bitwise identical. (OBI) Digital entity OBI has this as a child of "non realizable information entity"; we may need to update the entire hierarchy (Maryann Martone). Investigation design http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Investigation design http://obi.sourceforge.net/ontology/OBI.owl#OBI_335 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 Data transformation http://obi.sourceforge.net/ontology/OBI.owl#OBI_95 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Data transformation 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://obi.sourceforge.net/ontology/OBI.owl#OBI_69 Protocol application Protocol application 2007-10-05 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Image http://obi.sourceforge.net/ontology/OBI.owl#OBI_325 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 Image http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 Investigation record Investigation record http://obi.sourceforge.net/ontology/OBI.owl#OBI_46 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Report http://obi.sourceforge.net/ontology/OBI.owl#OBI_322 _7_12 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Report http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_129 Cell line Cell line http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. _1_3.3 2008-02-21 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Reference treatment 2008-02-21 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Reference treatment http://obi.sourceforge.net/ontology/OBI.owl#Reference_treatment This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. 2007-10-05 Investigator http://obi.sourceforge.net/ontology/OBI.owl#OBI_288 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug Investigator Control role This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex-OBI-proxy.owl#birnlex_11016 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_171 Control role http://ontology.neuinfo.org/NIF/Backend/BIRNLex-OBI-proxy.owl#birnlex_11044 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2008-02-21 Device Device http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary 2007-10-05 http://obi.sourceforge.net/ontology/OBI.owl#OBI_400002 2007-10-05 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug http://obi.sourceforge.net/ontology/OBI.owl#Vehicle_control_treatment This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Vehicle control treatment 2008-02-21 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Vehicle control treatment 2008-02-21 An amino acid precursor of dopamine with antiparkinsonian properties. L-DOPA is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, L-DOPA is decarboxylated to dopamine and stimulates the dopaminergic receptors. (Adapted from NCI Thesaurus) Levodopa is naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. (PubChem) Pharmacology: Levodopa (L-dopa) is used to replace dopamine lost in Parkinson's disease because dopamine itself cannot cross the blood-brain barrier where its precursor can. However, L-DOPA is converted to dopamine in the periphery as well as in the CNS, so it is administered with a peripheral DDC (dopamine decarboxylase) inhibitor such as carbidopa, without which 90% is metabolised in the gut wall, and with a COMT inhibitor if possible; this prevents about a 5% loss. The form given therapeutically is therefore a prodrug which avoids decarboxylation in the stomach and periphery, can cross the blood-brain barrier, and once in the brain is converted to the neurotransmitter dopamine by the enzyme aromatic-L-amino-acid decarboxylase. Mechanism of action: Striatal dopamine levels in symptomatic Parkinson's disease are decreased by 60 to 80%, striatal dopaminergic neurotransmission may be enhanced by exogenous supplementation of dopamine through administration of dopamine's precursor, levodopa. A small percentage of each levodopa dose crosses the blood-brain barrier and is decarboxylated to dopamine. This newly formed dopamine then is available to stimulate dopaminergic receptors, thus compensating for the depleted supply of endogenous dopamine. Drug type: Approved. Small Molecule. Drug category: Antidyskinetics. Antiparkinson Agents. Dopamine Agents L-Dopa http://obi.sourceforge.net/ontology/OBI.owl#OBI_43 http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug 2007-10-05 2007-10-05 This is a proxy class to be replaced by its OBI equivalent, once there is an official release built off BFO v1.1 that can be successfully classified using Pellet v1.5.0 in Protege. Data set http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#graph_position_temporary Data set