NIF-Molecule: contains molecules and proteins from SAO-CORE and NIF-Molecule. sao1246280606 C0597548 Synthetic Enzyme April 22, 2009 uncurated http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Molecule.owl#sao1440704204 Synthetic Enzyme Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases (MSH). OrphanA4 receptor - unspecified 2 2007-09-19 OrphanA4 receptor - unspecified 2 2007-09-19 2007-09-06 Kir6.2 channel aa sequence Kir6.2 channel aa sequence mlsrkgiipeeyvltrlaedpaepryrarqrrarfvskkgncnvahknireqgrflqdvfttlvdlkwphtlliftmsflcswllfamawwliafahgdlapsegtaepcvtsihsfssaflfsievqvtigfggrmvteecplaililivqnivglminaimlgcifmktaqahrraetlifskhavialrhgrlcfmlrvgdlrksmiisatihmqvvrkttspegevvplhqvdipmengvggnsiflvapliiyhvidansplydlapsdlhhhqdleiivilegvvettgittqartsyladeilwgqrfvpivaeedgrysvdyskfgntvkvptplctarqldedhsllealtlasargplrkrsvpmakakpkfsispdsls 2007-09-06 Sstr3 mRNA (NM 009218.2) Sstr3 mRNA (NM 009218.2) 2007-09-19 2007-09-19 RefSeq:NM 009218.2 17p11.2 TRPV2 gene NM 016113 2007-09-06 2007-09-06 TRPV2 gene TRPV2 2q32 GI:295144 2007-09-19 Lgr7 gene Lgr7 2007-09-19 Lgr7 gene Adora1 mRNA (NM 001008533.2) RefSeq:NM 001008533.2 2007-09-19 Adora1 mRNA (NM 001008533.2) 2007-09-19 SP:Q14439 Other Orphan Gene receptor - unspecified 41 2007-09-19 Other Orphan Gene receptor - unspecified 41 2007-09-19 May 1, 2009 Group I metabotropic glutamate receptor. Metabotropic glutamate receptor 5, also known as mGluR5 or GRM5, is a human gene. Anita Bandrowski MGluR5 GRM5 Metabotropic glutamate receptor 5 2007-09-19 SP:P30936 2007-09-19 Sst3 receptor Sst3 receptor Il8rb mRNA (NM 017183.1) 2007-09-19 RefSeq:NM 017183.1 Il8rb mRNA (NM 017183.1) 2007-09-19 PTGFR mRNA (NM 000959.3) 2007-09-19 PTGFR mRNA (NM 000959.3) RefSeq:NM 000959.3 2007-09-19 F-actin sao856608566 uncurated F-actin CCL22 2007-09-19 CCL22 2007-09-19 AT2 2007-09-19 AT2 receptor IUPHAR:2.1:ANG:2:AT2: 2007-09-19 AT2 receptor SP:O60883 OrphanA4 receptor - unspecified 2 OrphanA4 receptor - unspecified 2 2007-09-19 2007-09-19 2007-09-19 Sstr3 gene sst3 Sstr3 gene Smstr-3 Smstr3 2007-09-19 GI:20607 Sstr3 15 46.3 cM 2007-09-06 Inwardly rectifying potassium channel - type 7 2007-09-06 Inwardly rectifying potassium channel - type 7 TRPV2 VRL-1 2007-09-06 2007-09-06 GRC OTRPC2 TRPV2 2007-09-19 2007-09-19 Lgr7 mRNA (NM 201417.1) 2007-09-19 RefSeq:NM 201417.1 2007-09-19 Lgr7 mRNA (NM 201417.1) 2007-09-19 Other Orphan Gene receptor - unspecified 41 Other Orphan Gene receptor - unspecified 41 2007-09-19 Adora1 mRNA (NM 001039510.1) 2007-09-19 RefSeq:NM 001039510.1 Adora1 mRNA (NM 001039510.1) 2007-09-19 IUPHAR:2.1:PG:2:EP1: EP1 2007-09-19 EP1 receptor 2007-09-19 EP1 receptor 2007-09-19 PTGFR gene 2007-09-19 GI:5737 PTGFR gene PTGFR 1p31.1 MGluR6 Metabotropic glutamate receptor 6 GRM6 Anita Bandrowski Group III metabotropic glutamate receptor. Glutamate receptor, metabotropic 6, also known as GRM6, is a human gene. May 1, 2009 P2Y1 receptor 2007-09-19 2007-09-19 SP:P49651 P2Y1 receptor 2007-09-19 GPR37L1 gene GI:9283 GPR37L1 1q32.1 GPR37L1 gene 2007-09-19 AT2 receptor SP:P50052 2007-09-19 AT2 receptor 2007-09-19 Sst3 receptor 2007-09-19 Sst3 receptor SP:P30935 2007-09-19 FP FP receptor FP receptor 2007-09-19 IUPHAR:2.1:PG:6:FP: 2007-09-19 2007-09-06 K2p10.1 TREK-2 2007-09-06 KCNK10 K2p10.1 2007-09-06 11p15.1 KCNJ11 gene KCNJ11 KCNJ11 gene NM 000525 2007-09-06 2007-09-19 Taar3 mRNA (NM 001008429.1) RefSeq:NM 001008429.1 2007-09-19 Taar3 mRNA (NM 001008429.1) OrphanA9 receptor OrphanA9 receptor 2007-09-19 2007-09-19 2007-09-06 2007-09-06 Kv3.3 minimum pore seqence Kv3.3 minimum pore seqence RASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIV 2007-09-19 ETA receptor 2007-09-19 IUPHAR:2.1:ET:1:ETA: ETA receptor ETA 2007-09-19 A1 receptor 2007-09-19 SP:Q60612 A1 receptor CCL24 CCL24 2007-09-19 2007-09-19 2007-09-06 2007-09-06 TRPV3 TRPV3 GPR176 mRNA (NM 007223.1) 2007-09-19 GPR176 mRNA (NM 007223.1) RefSeq:NM 007223.1 2007-09-19 Orphan (trace amine-like) receptor - unspecified 1 2007-09-19 Orphan (trace amine-like) receptor - unspecified 1 2007-09-19 RefSeq:NM 008772.2 2007-09-19 2007-09-19 P2ry1 mRNA (NM 008772.2) P2ry1 mRNA (NM 008772.2) MGluR3 Group II metabotropic glutamate receptor. Glutamate receptor, metabotropic 3, also known as GRM3, is a human gene. Anita Bandrowski May 1, 2009 GRM3 Metabotropic glutamate receptor 3 FP receptor FP receptor 2007-09-19 2007-09-19 SP:P43088 2007-09-19 2007-09-19 EP1 receptor SP:P34995 EP1 receptor 2007-09-19 RefSeq:NM 001051.2 SSTR3 mRNA (NM 001051.2) 2007-09-19 SSTR3 mRNA (NM 001051.2) RefSeq:NM 053897.2 F2rl1 mRNA (NM 053897.2) 2007-09-19 F2rl1 mRNA (NM 053897.2) 2007-09-19 2007-09-06 Kir6.2 minimum pore seqence TLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIF Kir6.2 minimum pore seqence 2007-09-06 TRPV2 minimum pore seqence TRPV2 minimum pore seqence 2007-09-06 2007-09-06 DLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMG 2007-09-19 2007-09-19 OrphanA9 receptor - unspecified 1 OrphanA9 receptor - unspecified 1 GPR176 gene GPR176 gene GI:11245 GPR176 15q15.1 2007-09-19 2007-09-19 Endothelin receptor 2007-09-19 2007-09-19 Endothelin receptor Adora1 gene 2007-09-19 1 E4 A1AR AI848715 A1R BB176431 2007-09-19 Adora1 GI:11539 Adora1 gene TRPV2 channel aa sequence 2007-09-06 TRPV2 channel aa sequence 2007-09-06 mtspssspvfrletldggqedgseadrgkldfgsglppmesqfqgedrkfapqirvnlnyrkgtgasqpdpnrfdrdrlfnavsrgvpedlaglpeylsktskyltdseytegstgktclmkavlnlkdgvnacilpllqidrdsgnpqplvnaqctddyyrghsalhiaiekrslqcvkllvenganvharacgrffqkgqgtcfyfgelplslaactkqwdvvsyllenphqpaslqatdsqgntvlhalvmisdnsaenialvtsmydgllqagarlcptvqledirnlqdltplklaakegkieifrhilqrefsglshlsrkftewcygpvrvslydlasvdsceensvleiiafhcksphrhrmvvleplnkllqakwdllipkfflnflcnliymfiftavayhqptlkkqaaphlkaevgnsmlltghilillggiyllvgqlwyfwrrhvfiwisfidsyfeilflfqalltvvsqvlcflaiewylpllvsalvlgwlnllyytrgfqhtgiysvmiqkvilrdllrflliylvflfgfavalvslsqeawrpeaptgpnatesvqpmegqedegngaqyrgileaslelfkftigmgelafqeqlhfrgmvlllllayvlltyilllnmlialmsetvnsvatdswsiwklqkaisvlemengywwcrkkqragvmltvgtkpdgspderwcfrveevnwasweqtlptlcedpsgagvprtlenpvlasppkededgaseenyvpvqllqsn P2ry1 gene 2007-09-19 P2Y1 P2ry1 gene P2ry1 2007-09-19 GI:18441 3 D We need to determine whether this should be under Pigment or Cellular Inclusion. Lipofuscin uncurated A naturally occurring lipid pigment with histochemical characteristics similar to ceroid. It accumulates in various normal tissues and apparently increases in quantity with age (MSH). sao941755985 C0023789 Lipofuscin GI:5731 PTGER1 gene 19p13.1 PTGER1 gene 2007-09-19 2007-09-19 PTGER1 2007-09-19 Taar3 gene GI:494319 Taar3 gene Taar3 2007-09-19 1p12 2007-09-19 CCL23 2007-09-19 CCL23 Adra1a gene MGC130524 [a]1a 14 D1 Adra1c Adra1a GI:11549 Adra1a gene 2007-09-19 2007-09-19 GRM4 Metabotropic glutamate receptor 4 May 1, 2009 Group III metabotropic glutamate receptor. Glutamate receptor, metabotropic 4, also known as GRM4, is a human gene. Anita Bandrowski MGluR4 Kir7.1 minimum pore seqence MMLVFSASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFV 2007-09-06 2007-09-06 Kir7.1 minimum pore seqence 2007-09-19 2007-09-19 Beta-endorphin Beta-endorphin b-endorphin 2007-09-19 2007-09-19 KTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIG 2007-09-06 2007-09-06 K2p10.1 minimum pore seqence K2p10.1 minimum pore seqence 2007-09-19 2007-09-19 F2rl1 gene F2rl1 gene F2rl1 GI:116677 Par2 Par-2 2q12 SP:P35374 2007-09-19 AT2 receptor 2007-09-19 AT2 receptor K2p10.1 channel aa sequence mkfpietprkqvnwdpkvavpaaapvcqpksatngqppapaptptprlsissratvvarmegtsqgglqtvmkwktvvaifvvvvvylvtgglvfraleqpfessqkntialekaeflrdhvcvspqeletliqhaldadnagvspignssnnsshwdlgsafffagtvittigygniapsteggkifcilyaifgiplfgfllagigdqlgtifgksiarvekvfrkkqvsqtkirvistilfilagcivfvtipavifkyiegwtalesiyfvvvtlttvgfgdfvaggnaginyrewykplvwfwilvglayfaavlsmigdwlrvlskktkeevgeikahaaewkanvtaefretrrrlsveihdklqraatirsmerrrlgldqrahsldmlspekrsvfaaldtgrfkassqesinnrpnnlrlkgpeqlnkhgqgasedniinkfgstsrltkrknkdlkktlpedvqkiyktfrnysldeekkeeetekmcnsdnsstamltdciqqhaelengmiptdtkdrepennslledrn 2007-09-06 K2p10.1 channel aa sequence 2007-09-06 PTGER1 mRNA (NM 000955.2) PTGER1 mRNA (NM 000955.2) RefSeq:NM 000955.2 2007-09-19 2007-09-19 CCL27 2007-09-19 2007-09-19 CCL27 Gm1012 2007-09-19 GI:381413 Gpr176 Gpr176 gene 2 E5 MGC62396 Gpr176 gene 2007-09-19 RP23-450P9.1 RXFP2 GI:122042 2007-09-19 2007-09-19 RXFP2 gene 13q12.3 RXFP2 gene 4q31.22 2007-09-19 EDNRA EDNRA gene EDNRA gene GI:1909 2007-09-19 mdssnckviapllsqryrrmvtkdghstlqmdgaqrglaylrdawgilmdmrwrwmmlvfsasfvvhwlvfavlwyvlaemngdleldhdappenhticvkyitsftaafsfsletqltigygtmfpsgdcpsaiallaiqmllglmleafitgafvakiarpknrafsirftdiavvahmdgkpnlifqvantrpspltsvrvsavlyqerengklyqtsvdfhldgissdecpffifpltyyhsitpssplatllqhenpshfelvvflsamqegtgeicqrrtsylqseimlhhcfaslltrgskceyqikmenfdktvpefptplvskspnrtdldihingqsidnfqisetglte Kir7.1 channel aa sequence 2007-09-06 Kir7.1 channel aa sequence 2007-09-06 KCNK10 gene 2007-09-06 14q31 KCNK10 gene 2007-09-06 KCNK10 NM 021161 2007-09-19 Dynorphin 2007-09-19 Dynorphin GI:11609 Agtr2 2007-09-19 2007-09-19 RP23-368N20.1 Agtr2 gene AI316812 Agtr2 gene AW107640 X 12.5 cM 2007-09-19 2007-09-19 Orphan (trace amine-like) receptor - unspecified 2 Orphan (trace amine-like) receptor - unspecified 2 EP1 receptor 2007-09-19 2007-09-19 EP1 receptor SP:P35375 SP:Q80WT4 2007-09-19 Other Orphan Gene receptor - unspecified 41 2007-09-19 Other Orphan Gene receptor - unspecified 41 2007-09-19 2007-09-19 CCL26 CCL26 Calretinin Calretinin 2007-09-05 2007-09-05 RefSeq:NM 000674.1 2007-09-19 ADORA1 mRNA (NM 000674.1) ADORA1 mRNA (NM 000674.1) 2007-09-19 ETA receptor ETA receptor 2007-09-19 SP:P25101 2007-09-19 RefSeq:NM 130806.2 RXFP2 mRNA (NM 130806.2) 2007-09-19 RXFP2 mRNA (NM 130806.2) 2007-09-19 2007-09-19 Gpr 3q35 Gm1012 Gpr176 gene GI:117257 Gpr176 gene Gpr176 RBU-15 2007-09-19 2007-09-06 Kir7.1 2007-09-06 Kir7.1 K2p12.1 2007-09-06 KCNK12 K2p12.1 2007-09-06 THIK-2 2007-09-19 Orphan (Mas-related) receptor - unspecified 6 Orphan (Mas-related) receptor - unspecified 6 2007-09-19 SP:Q86SM5 EP1 42kDa 2007-09-19 Ptger1 gene 8 38.0 cM Ptger1 gene 2007-09-19 Ptger1 GI:19216 Ptgerep1 Xq22-q23 AGTR2 gene AGTR2 gene 2007-09-19 GI:186 AGTR2 2007-09-19 2007-09-19 2007-09-19 Sstr3 mRNA (NM 133522.1) Sstr3 mRNA (NM 133522.1) RefSeq:NM 133522.1 2007-09-19 2007-09-19 CXC Chemokine CXC Chemokine 2007-09-19 ETA receptor SP:Q61614 ETA receptor 2007-09-19 Other Orphan Gene receptor - unspecified 41 2007-09-19 2007-09-19 SP:Q64017 Other Orphan Gene receptor - unspecified 41 Rat chromosome 2 2007-09-19 2007-09-19 Rat chromosome 2 2q37 2007-09-06 NM 002242 2007-09-06 KCNJ13 KCNJ13 gene KCNJ13 gene 2007-09-19 2007-09-19 2007-09-19 Gpr75 mRNA (NM 175490.3) RefSeq:NM 175490.3 Gpr75 mRNA (NM 175490.3) 2007-09-19 2007-09-19 Dynorphin A Dynorphin A 2007-09-19 Orphan (Mas-related) receptor - unspecified 6 2007-09-19 Orphan (Mas-related) receptor - unspecified 6 2007-09-19 2007-09-06 Two pore potassium channel - type 12 Two pore potassium channel - type 12 2007-09-06 AGTR2 mRNA (NM 000686.3) AGTR2 mRNA (NM 000686.3) 2007-09-19 2007-09-19 RefSeq:NM 000686.3 Sstr3 gene 2007-09-19 7q34 Smstr28 Sstr3 Sstr3 gene 2007-09-19 GI:171044 2007-09-19 RXFP2 receptor RXFP2 receptor 2007-09-19 SP:Q8WXD0 2007-09-19 EDNRA mRNA (NM 001957.1) EDNRA mRNA (NM 001957.1) 2007-09-19 RefSeq:NM 001957.1 CCL28 CCL28 2007-09-19 2007-09-19 2007-09-19 Gpr176 mRNA (NM 201367.1) 2007-09-19 Gpr176 mRNA (NM 201367.1) RefSeq:NM 201367.1 SP:Q8NGU9 2007-09-19 Other Orphan Gene receptor - unspecified 17 Other Orphan Gene receptor - unspecified 17 2007-09-19 OrphanA15 receptor - unspecified 1 OrphanA15 receptor - unspecified 1 2007-09-19 SP:O89039 2007-09-19 P2Y4R X C2 P2ry4 gene 2007-09-19 P2ry4 gene 2007-09-19 P2ry4 P2Y4 RP23-281K21.8 GI:57385 2007-09-19 2007-09-19 CXCL5 CXCL5 March 18, 2009 Proteoglycan Proteoglycan 2007-09-05 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Molecule.owl#sao500241072 RefSeq:NM 008309.2 2007-09-19 2007-09-19 Htr1d mRNA (NM 008309.2) Htr1d mRNA (NM 008309.2) RefSeq:XM 001062802.1 2007-09-19 Gpr37l1 mRNA (XM 001062802.1) 2007-09-19 Gpr37l1 mRNA (XM 001062802.1) GRFVLLAALIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAHGVAEPELRAFLRHYEAALAAGVRADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFL K2p12.1 minimum pore seqence K2p12.1 minimum pore seqence 2007-09-06 2007-09-06 2007-09-19 2007-09-19 RefSeq:NM 000680.1 2007-09-19 ADRA1A mRNA (NM 000680.1) ADRA1A mRNA (NM 000680.1) 2007-09-19 VGCNL1 gene 2007-09-06 VGCNL1 gene 13q32.3 NM 052867 VGCNL1 2007-09-06 2007-09-19 2007-09-19 Gpr109a mRNA (NM 181476.1) RefSeq:NM 181476.1 Gpr109a mRNA (NM 181476.1) KCNV2 gene KCNV2 2007-09-06 2007-09-06 9p24.2 NM 133497 KCNV2 gene 2007-09-19 2007-09-19 6q31 GI:25360 Tshr gene TSHRA 2007-09-19 Tshr gene Tshr 2007-09-19 2007-09-19 2007-09-19 RefSeq:NM 020621.2 P2ry4 mRNA (NM 020621.2) P2ry4 mRNA (NM 020621.2) Cmkor1 gene Cmkor1 GI:84348 2007-09-19 9q35 Cmkor1 gene 2007-09-19 Rdc1 uncurated C0536483 GluR2 April 15, 2010 GluR2 2007-09-05 2007-09-05 Chondroitin sulfate proteoglycan Chondroitin sulfate proteoglycan Other Orphan Gene receptor - unspecified 17 2007-09-19 Other Orphan Gene receptor - unspecified 17 2007-09-19 NM 021625 TRPV4 2007-09-06 TRPV4 gene 2007-09-06 TRPV4 gene 12q24.1 2007-09-19 2007-09-19 SP:Q15743 SPC/LPC receptor - unspecified 4 SPC/LPC receptor - unspecified 4 CXCL8 2007-09-19 2007-09-19 CXCL8 Maryann Martone Alpha bungarotoxin Levitan, I. B. and Kaczmarek, L. K. The Neuron: Cell and Molecular Biology. New York: Oxford University Press, 1991. A type of bungarotoxin derived from the venom of the Taiwanese cobra Bugarus multicinctus. It is a peptide of 74 amino acids that bind to the nicotinic acetylcholine receptor with high affinity. June 24, 2009 2007-09-19 2007-09-19 5-HT1D receptor 5-HT1D receptor 2007-09-19 SP:P28565 2007-09-19 2007-09-06 2007-09-06 2p22-21 NM 022055 KCNK12 KCNK12 gene KCNK12 gene 2007-09-19 2007-09-19 ADRA1A gene GI:148 8p21-p11.2 ADRA1A gene ADRA1A VGCNL1 voltage-gated channel like 1 VGCNL1 2007-09-06 2007-09-06 GI:353250 Gpr109a 2007-09-19 Gpr109a gene Pumag 12q15 Gpr109a gene rHM74b Hm74b Hm74 2007-09-19 Gpr109b 2007-09-06 2007-09-06 Kv8.2 minimum pore seqence RQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILY Kv8.2 minimum pore seqence 2007-09-19 TSH receptor SP:P21463 2007-09-19 TSH receptor 2007-09-05 2007-09-05 Parvalbumin Parvalbumin 2007-09-19 2007-09-19 SPC/LPC receptor - unspecified 1 SPC/LPC receptor - unspecified 1 14q31 GPR68 GI:8111 GPR68 gene 2007-09-19 2007-09-19 GPR68 gene Bdkrb1 mRNA (NM 030851.1) Bdkrb1 mRNA (NM 030851.1) 2007-09-19 RefSeq:NM 030851.1 2007-09-19 2007-09-19 2007-09-19 RefSeq:NM 199243.1 GPR150 mRNA (NM 199243.1) GPR150 mRNA (NM 199243.1) 2007-09-19 Rdc1 Cmkor1 Cmkor1 gene GI:12778 Cmkor1 gene 2007-09-19 AW541270 1 55.6 cM Alpha1A receptor 2007-09-19 Alpha1A receptor SP:P35348 2007-09-19 2007-09-06 2007-09-06 LRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELV Kca4.1 minimum pore seqence Kca4.1 minimum pore seqence 2007-09-19 OrphanA4 receptor - unspecified 2 2007-09-19 OrphanA4 receptor - unspecified 2 Two pore potassium channel - type 13 2007-09-06 Two pore potassium channel - type 13 2007-09-06 2007-09-19 GI:25323 5q36 Htr1d Htr1d gene Htr1d gene 2007-09-19 5HT1D 2007-09-19 2007-09-19 P2RY10 mRNA (NM 198333.1) P2RY10 mRNA (NM 198333.1) RefSeq:NM 198333.1 2007-09-19 2007-09-19 RefSeq:NM 207173.1 2007-09-19 2007-09-19 NPSR1 mRNA (NM 207173.1) NPSR1 mRNA (NM 207173.1) OrphanA15 receptor - unspecified 1 2007-09-19 SP:P56485 2007-09-19 OrphanA15 receptor - unspecified 1 RefSeq:NM 011648.3 Tshr mRNA (NM 011648.3) Tshr mRNA (NM 011648.3) 2007-09-19 2007-09-19 2007-09-19 GPR68 mRNA (NM 003485.3) RefSeq:NM 003485.3 GPR68 mRNA (NM 003485.3) 2007-09-19 CXCL9 2007-09-19 CXCL9 2007-09-19 Nitric oxide synthase NOS Nitric oxide synthase April 8, 2010 2007-09-05 SP:Q9JJS7 2007-09-19 P2Y4 receptor P2Y4 receptor 2007-09-19 2007-09-19 2007-09-19 Cmkor1 mRNA (NM 007722.2) Cmkor1 mRNA (NM 007722.2) RefSeq:NM 007722.2 April 19, 2010 2007-09-19 alpha 1A Alpha 1A- adrenoreceptor Alpha 1A-adrenoceptor IUPHAR:2.1:ADR:1:A1A: Alpha1A receptor Alpha-1C adrenergic receptor Alpha-1A adrenergic receptor Alpha1A receptor A1A Alpha adrenergic receptor 1c Adrenergic receptor with high affinity binding to WB-4101. alpha1A Bdkrb1 gene 2007-09-19 2007-09-19 Bdkrb1 gene 6q32 Bdkrb Bdkrb1 BKR GI:81509 b1bkr GPR150 gene GPR150 5q15 GI:285601 GPR150 gene 2007-09-19 2007-09-19 2007-09-19 Other Orphan Gene receptor - unspecified 3 SP:O75388 2007-09-19 Other Orphan Gene receptor - unspecified 3 2007-09-06 K2p12.1 channel aa sequence 2007-09-06 K2p12.1 channel aa sequence mssrsprppprrsrrrlprpsccccccrrshlnedtgrfvllaaliglylvagatvfsalespgeaeararwgatlrnfsaahgvaepelraflrhyeaalaagvradalrprwdfpgafyfvgtvvstigfgmttpatvggkafliayglfgcagtilffnlfleriisllafimracrerqlrrsgllpatfrrgsalseadslagwkpsvyhvllilglfavllsccasamytsvegwdyvdslyfcfvtfstigfgdlvssqhaayrnqglyrlgnflfillgvcciyslfnvisilikqvlnwmlrklscrccarccpapgaplarrnaitpgsrlrrrlaalgadpaardsdaegrrlsgelismrdltasnkvslallqkqlsetangyprsvcvntrqngfsggvgalgimnnrlaetsasr Gpr37l1 GI:252939 Gpr37l1 gene 13q13 Gpr37l1 gene 2007-09-19 2007-09-19 Htr1d mRNA (NM 012852.1) 2007-09-19 2007-09-19 Htr1d mRNA (NM 012852.1) RefSeq:NM 012852.1 Tshr gene 2007-09-19 Tshr gene GI:22095 12 37.0 cM 2007-09-19 hypothroid Tshr hyt pet NPS receptor NPS receptor 2007-09-19 SP:Q8BZP8 2007-09-19 2007-09-19 2007-09-19 2007-09-19 P2Y1 receptor 2007-09-19 SP:P49650 P2Y1 receptor 2007-09-19 SPC/LPC receptor - unspecified 4 SP:Q8BFQ3 2007-09-19 SPC/LPC receptor - unspecified 4 2007-09-19 2007-09-19 SP:P97718 Alpha1A receptor Alpha1A receptor 2007-09-19 RefSeq:NM 008966.3 Ptgfr mRNA (NM 008966.3) 2007-09-19 Ptgfr mRNA (NM 008966.3) 1 E4 CAG-18 AW047233 Gpr37l1 gene D0Kist8 2007-09-19 Gpr37l1 gene GI:171469 Gpr37l1 2007-09-19 Gpr4 mRNA (NM 001025680.1) Gpr4 mRNA (NM 001025680.1) 2007-09-19 RefSeq:NM 001025680.1 2007-09-19 Dopamine receptor Dopamine receptor DA DA receptor April 19, 2010 2007-09-19 Receptor that binds dopamine. These receptors are either D1-like receptors or D2-like receptors, where the D1 receptors (D1 and D5) increase adenylyl cyclase activity and the D2-like receptors (D2, D3, and D4) decrease adenylyl cyclase activity. The two families are distinguishable by expression patterns and pharmacology, and involved with different disease states. D1-like receptor family is involved with the brain's reward system and schizophrenia, while D2-like family is involved with motor control systems and Parkinsons disease. DVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMS TRPV3 minimum pore seqence 2007-09-06 TRPV3 minimum pore seqence 2007-09-06 Mouse chromosome 8 2007-09-19 2007-09-19 Mouse chromosome 8 RefSeq:NM 031680.1 2007-09-19 P2ry4 mRNA (NM 031680.1) 2007-09-19 P2ry4 mRNA (NM 031680.1) TSH receptor TSH receptor 2007-09-19 2007-09-19 SP:P47750 9330128H10Rik Npsr1 gene Npsr1 Gpr154 2007-09-19 PGR14 Npsr1 gene GPRA VRR1 GI:319239 9 A3-A4 2007-09-19 2007-09-06 Cav3.2 minimum pore seqence QVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLM Cav3.2 minimum pore seqence 2007-09-06 P2RY10 gene P2RY10 Xq21.1 P2RY10 gene 2007-09-19 2007-09-19 GI:27334 Gpr37l1 mRNA (NM 134438.1) RefSeq:NM 134438.1 Gpr37l1 mRNA (NM 134438.1) 2007-09-19 2007-09-19 RefSeq:NM 033304.1 ADRA1A mRNA (NM 033304.1) 2007-09-19 ADRA1A mRNA (NM 033304.1) 2007-09-19 2007-09-19 2007-09-19 P2RY1 mRNA (NM 002563.2) 2007-09-19 2007-09-19 P2RY1 mRNA (NM 002563.2) RefSeq:NM 002563.2 BB131428 GI:238377 2007-09-19 OGR1 Gpr68 Gpr68 gene 2007-09-19 Gpr68 gene 12 E 2007-09-19 Ptgfr PGF fp 3 75.8 cM Ptgfr gene 2007-09-19 Ptgfr gene AI957154 GI:19220 TRPV3 TRPV3 gene 2007-09-06 17p13.3 TRPV3 gene NM 145068 2007-09-06 D2L 2007-09-19 D2 Dopamine D2 receptor D2S/D2L Dopamine receptor that inhibits adenylyl cyclase activity, potentiate calcium evoked release of arachadonic acid, increase potassium channel opening and in some cells decrease intracellular calcium concentrations. D2 receptors have a high affinity for antipsychotic drugs and have higher levels of expression in mammalian hippocampus and hypothalamus. D2 receptor D2 receptor April 16, 2010 D(2) dopamine receptor D2S IUPHAR:2.1:DA:2:D2A: GI:308408 Gpr4 1q21 MGC116369 Gpr4 gene 2007-09-19 2007-09-19 Gpr4 gene 2007-09-19 2007-09-19 Sst4 receptor Sst4 receptor sst4 IUPHAR:2.1:SRIF:5:SRIF2B: 2007-09-19 2007-09-19 2007-09-19 TSHR mRNA (NM 001018036.1) RefSeq:NM 001018036.1 TSHR mRNA (NM 001018036.1) 2007-09-19 Npsr1 mRNA (NM 175678.2) RefSeq:NM 175678.2 2007-09-19 2007-09-19 Npsr1 mRNA (NM 175678.2) sao149790201 uncurated Beta Neurexin Beta Neurexin 10 A4 Taar3 gene Taar3 gene GI:493809 2007-09-19 2007-09-19 Taar3 2007-09-06 2007-09-06 Kir6.2 Kir6.2 BIR April 22, 2009 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Molecule.owl#sao1671627152 uncurated Neurotrophin Neurotrophin sao1473913158 C0132298 Family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system, which are critical to neuronal growth, regeneration, survival, and differentiation (CSP). P2RY10 mRNA (NM 014499.2) P2RY10 mRNA (NM 014499.2) RefSeq:NM 014499.2 2007-09-19 2007-09-19 2007-09-19 2007-09-19 2007-09-06 CACNA1I gene CACNA1I gene NM 021096 2007-09-06 CACNA1I 22q13.1 FP receptor SP:P43117 FP receptor 2007-09-19 2007-09-19 GPR37L1 mRNA (NM 004767.2) 2007-09-19 GPR37L1 mRNA (NM 004767.2) 2007-09-19 RefSeq:NM 004767.2 ADRA1A mRNA (NM 033303.2) 2007-09-19 ADRA1A mRNA (NM 033303.2) RefSeq:NM 033303.2 2007-09-19 P2RY1 gene GI:5028 P2RY1 2007-09-19 3q25.2 P2RY1 gene 2007-09-19 Gpr68 mRNA (NM 175493.2) Gpr68 mRNA (NM 175493.2) 2007-09-19 RefSeq:NM 175493.2 2007-09-19 Galr1 mRNA (NM 012958.1) 2007-09-19 2007-09-19 Galr1 mRNA (NM 012958.1) RefSeq:NM 012958.1 VR-OAC TRPV4 2007-09-06 2007-09-06 OTRPC4 TRPV4 A membrane protein expressed in many tissues and concentrated in the synapses of neurons. It is implicated as a regulator of synapse formation and neural plasticity. Its proteolysis generates amyloid beta. sao1143333050 Amyloid Precursor Protein Amyloid Precursor Protein uncurated Sarah M. Maynard APP 2007-09-19 2007-09-19 Edg4 mRNA (NM 020028.3) 2007-09-19 2007-09-19 RefSeq:NM 020028.3 Edg4 mRNA (NM 020028.3) SP:O35811 2007-09-19 P2Y4 receptor 2007-09-19 P2Y4 receptor RefSeq:XM 001080642.1 2007-09-19 2007-09-19 Gpr120 mRNA (XM 001080642.1) Gpr120 mRNA (XM 001080642.1) V1B receptor SP:P47901 V1B receptor 2007-09-19 2007-09-19 GI:553 1q32 AVPR1B gene 2007-09-19 AVPR1B 2007-09-19 AVPR1B gene NeurabinI http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Molecule.owl#sao1281431356 uncurated PDZ containing proteins with F-actin binding protein activity. NeurabinI sao1535366556 April 22, 2009 2007-09-19 Anaphylatoxin receptor Anaphylatoxin receptor 2007-09-19 2007-09-19 2007-09-19 RefSeq:NM 000369.2 TSHR mRNA (NM 000369.2) TSHR mRNA (NM 000369.2) OrphanA13 receptor - unspecified 2 2007-09-19 2007-09-19 OrphanA13 receptor - unspecified 2 2007-09-06 Human chromosome 22 Human chromosome 22 2007-09-06 OrphanA4 receptor - unspecified 2 SP:Q99JG2 2007-09-19 OrphanA4 receptor - unspecified 2 2007-09-19 2007-09-19 2007-09-19 ADRA1A mRNA (NM 033302.1) ADRA1A mRNA (NM 033302.1) RefSeq:NM 033302.1 2007-09-19 2007-09-19 P2RY14 mRNA (NM 014879.2) P2RY14 mRNA (NM 014879.2) RefSeq:NM 014879.2 P2Y1 receptor P2Y1 receptor SP:P47900 2007-09-19 2007-09-19 2007-09-19 SPC/LPC receptor - unspecified 4 2007-09-19 SPC/LPC receptor - unspecified 4 2007-09-19 2007-09-19 PTGFR mRNA (NM 001039585.1) PTGFR mRNA (NM 001039585.1) RefSeq:NM 001039585.1 2007-09-19 P2ry4 gene P2ry4 Xq31 GI:63843 2007-09-19 P2Y4 P2ry4 gene IPA2 8 33.5 cM Edg4 gene Edg4 gene GI:53978 Edg4 2007-09-19 2007-09-19 LPA2 2007-09-06 TRPV3 channel aa sequence 2007-09-06 mkahpkemvplmgkrvaapsgnpailpekrpaeitptkksahffleiegfepnptvaktsppvfskpmdsnirqcisgncddmdspqspqddvtetpsnpnspsaqlakeeqrrkkrrlkkrifaavsegcveelvellvelqelcrrrhdedvpdflmhkltasdtgktclmkallninpntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaagadvnahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnnilhalvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilkyilsreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhemltleplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrpreeeaiphplalthkmgwlqllgrmfvliwamcisvkegiaifllrpsdlqsilsdawfhfvffiqavlvilsvflylfaykeylaclvlamalgwanmlyytrgfqsmgmysvmiqkvilhdvlkflfvyivfllgfgvalasliekcpkdnkdcssygsfsdavlelfkltiglgdlniqqnskypilflfllityviltfvlllnmlialmgetvenvskeseriwrlqrartilefekmlpewlrsrfrmgelckvaeddfrlclrinevkwtewkthvsflnedpgpvrrtdfnkiqdssrnnskttlnafeeveefpetsv TRPV3 channel aa sequence 2007-09-19 2007-09-19 V1B receptor IUPHAR:2.1:VASO:3:V1B: V1B V1B receptor 2007-09-19 Gpr120 mRNA (XM 215281.4) 2007-09-19 Gpr120 mRNA (XM 215281.4) RefSeq:XM 215281.4 TSHR gene 2007-09-19 TSHR 2007-09-19 GI:7253 14q31 TSHR gene Anaphylatoxin receptor - unspecified 1 2007-09-19 Anaphylatoxin receptor - unspecified 1 2007-09-19 OrphanA13 receptor - unspecified 2 OrphanA13 receptor - unspecified 2 SP:O00398 2007-09-19 2007-09-19 Additional agonists from V Ralevic and G Burnstock, Pharm. Rev., v50:n3, p413 (BB). P2Y1 2007-09-19 P2Y1 receptor 2007-09-19 P2Y1 receptor IUPHAR:2.1:NUCT:1:P2Y1: Cav3.2 channel aa sequence 2007-09-06 maesasppsssaaapaaepgvtteqpgprsppssppgleepldgadphvphpdlapiaffclrqttsprnwcikmvcnpwfecvsmlvillncvtlgmyqpcddmdclsdrckilqvfddfififfamemvlkmvalgifgkkcylgdtwnrldffivmagmveysldlqninlsairtvrvlrplkainrvpsmrilvnllldtlpmlgnvlllcffvffifgiigvqlwagllrnrcfleenftiqgdvalppyyqpeeddempficslsgdngimgcheipplkeqgrecclskddvydfgagrqdlnasglcvnwnryynvcrtgsanphkgainfdnigyawivifqvitlegwveimyyvmdahsfynfiyfilliivgsffminlclvviatqfsetkqrehrlmleqrqrylssstvasyaepgdcyeeifqyvchilrkakrralglyqalqsrrqalgpeapapakpgphakeprhyhgktkgqgdegrhlgsrhcqtlhgpaspgndhsgrelcpqhspldatphtlvqpipatlasdpascpccqhedgrrpsglgstdsgqegsgsgssaggedeadgdgarssedgasselgkeeeeeeqadgavwlcgdvwretraklrgivdskyfnrgimmailvntvsmgiehheqpeeltnileicnvvftsmfalemilklaafglfdylrnpynifdsiiviisiweivgqadgglsvlrtfrllrvlklvrfmpalrrqlvvlmktmdnvatfcmllmlfififsilgmhifgckfslrtdtgdtvpdrknfdsllwaivtvfqiltqedwnvvlyngmastspwaslyfvalmtfgnyvlfnllvailvegfqaegdanrsysdedqsssnieefdklqegldssgdpklcpipmtpnghldpslplgghlgpagaagpaprlslqpdpmlvalgsrkssvmslgrmsydqrslsssrssyygpwgrsaawasrrsswnslkhkppsaehesllsaergggarvcevaadegppraaplhtphahhihhgphlahrhrhhrrtlsldnrdsvdlaelvpavgahpraawraagpapghedcngrmpsiakdvftkmgdrgdrgedeeeidytlcfrvrkmidvykpdwcevredwsvylfspenrfrvlcqtiiahklfdyvvlafiflncitialerpqieagsterifltvsnyiftaifvgemtlkvvslglyfgeqaylrsswnvldgflvfvsiidivvslasaggakilgvlrvlrllrtlrplrvisrapglklvvetlisslkpignivliccaffiifgilgvqlfkgkfyhclgvdtrnitnrsdcmaanyrwvhhkynfdnlgqalmslfvlaskdgwvnimyngldavavdqqpvtnhnpwmllyfisfllivsffvlnmfvgvvvenfhkcrqhqeaeearrreekrlrrlekkrrkaqrlpyyatychtrllihsmctshyldifitfiiclnvvtmslehynqptsletalkycnymfttvfvleavlklvafglrrffkdrwnqldlaivllsvmgitleeieinaalpinptiirimrvlriarvlkllkmatgmralldtvvqalpqvgnlgllfmllffiyaalgvelfgklvcndenpcegmsrhatfenfgmafltlfqvstgdnwngimkdtlrdcthdersclsslqfvsplyfvsfvltaqfvlinvvvavlmkhlddsnkeaqedaemdaelelemahglgpgprlptgspgapgrgpggaggggdtegglcrrcyspaqenlwldsvsliikdslegeltiidnlsgsifhhysspagckkchhdkqevqlaeteafslnsdrsssillgddlsledptacppgrkdskgeldppepmrvgdlgecffplsstavspdpenflcemeeipfnpvrswlkhdssqappspfspdasspllpmpaeffhpavsasqkgpekgtgtgtlpkialqgswaslrsprvnctllrqatgsdtsldaspsssagslqttledsltlsdsprralgppapapgpraglspaarrrlslrgrglfslrglrahqrshssggstspgcthhdsmdpsdeegrggaggggagsehsetlsslsltslfcppppppapgltparkfsstsslaapgrphaaalahglarspswaadrskdppgraplpmglgplapppqplpgelepgdaaskrkr Cav3.2 channel aa sequence 2007-09-06 2007-09-06 2007-09-06 Calcium-activated potassium channel - type 5 Calcium-activated potassium channel - type 5 5-HT1E receptor SP:P28566 5-HT1E receptor 2007-09-19 2007-09-19 GPR55 gene 2007-09-19 2007-09-19 GPR55 GPR55 gene GI:9290 2q36.3 P2ry10 mRNA (XM 228500.4) 2007-09-19 2007-09-19 RefSeq:XM 228500.4 P2ry10 mRNA (XM 228500.4) 2007-09-19 MRGPRX1 mRNA (NM 147199.2) MRGPRX1 mRNA (NM 147199.2) RefSeq:NM 147199.2 2007-09-19 Intercellular Gap Junction Channel Maryann Martone Intercellular Gap Junction Channel Junctional complex consisting of two connexons that come together to form a communicating pore between two cells sao-1778046445 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Subcellular.owl#sao-17780464455 2007-09-19 BDKRB1 mRNA (NM 000710.2) 2007-09-19 BDKRB1 mRNA (NM 000710.2) RefSeq:NM 000710.2 SPC/LPC receptor - unspecified 1 2007-09-19 SP:P46093 SPC/LPC receptor - unspecified 1 2007-09-19 2007-09-19 2007-09-19 RefSeq:NM 002565.3 P2RY4 mRNA (NM 002565.3) P2RY4 mRNA (NM 002565.3) 2007-09-19 Neuropeptide S receptor 2007-09-19 Neuropeptide S receptor RefSeq:NM 016574.2 DRD2 mRNA (NM 016574.2) 2007-09-19 DRD2 mRNA (NM 016574.2) 2007-09-19 2007-09-19 2007-09-19 2007-09-19 A2B receptor 2007-09-19 SP:P29275 A2B receptor Gpr25 13q13 Gpr25 gene Gpr25 gene 2007-09-19 2007-09-19 GI:363993 2007-09-19 EDG6 EDG6 gene GI:8698 19p13.3 2007-09-19 EDG6 gene 2007-09-19 SPC/LPC receptor - unspecified 1 2007-09-19 SPC/LPC receptor - unspecified 1 Mc1r Mshra 2007-09-19 Tob Mc1r gene Mc1r gene e 2007-09-19 GI:17199 8 68.0 cM 2007-09-19 Gpr68 mRNA (XM 001065526.1) RefSeq:XM 001065526.1 Gpr68 mRNA (XM 001065526.1) 2007-09-19 2007-09-06 This class has been retired. April 17, 2009 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Molecule.owl#sao940366596 Ion channel Ion channel _5.2_5.2.1 http://www.ifomis.org/bfo/1.1/snap#Object 2007-09-19 2007-09-19 16 38.8 cM Htr1f gene GI:15557 Htr1f gene Htr1eb 2007-09-19 Htr1f 2007-09-19 EBI2 mRNA (NM 004951.3) 2007-09-19 RefSeq:NM 004951.3 2007-09-19 EBI2 mRNA (NM 004951.3) N-formylpeptide receptor - unspecified 2 2007-09-19 2007-09-19 SP:P33766 N-formylpeptide receptor - unspecified 2 Gpr105 P2ry14 A330108O13Rik P2ry14 gene 2007-09-19 3 29.5 cM GI:140795 2007-09-19 P2ry14 gene P2Y14 2007-09-19 2007-09-19 HTR1E gene 6q14-q15 GI:3354 HTR1E gene HTR1E P2ry10 mRNA (XM 001059224.1) P2ry10 mRNA (XM 001059224.1) 2007-09-19 2007-09-19 RefSeq:XM 001059224.1 KCNMC1 2007-09-06 Slo3 Kca5.1 Kca5.1 2007-09-06 5- HT1E April 19, 2010 5-HT1E 5-hydroxytryptamine 1E receptor S31 5-HT1E receptor IUPHAR:2.1:5HT:4:5HT1E: 5-HT-1E 5-HT1E receptor Serotonin receptor 1E 2007-09-19 RefSeq:NM 005683.2 GPR55 mRNA (NM 005683.2) 2007-09-19 2007-09-19 GPR55 mRNA (NM 005683.2) SP:Q61125 B1 receptor 2007-09-19 B1 receptor 2007-09-19 19q13.3 2007-09-19 GPR4 gene GPR4 GPR4 gene 2007-09-19 GI:2828 MRGPRG gene GI:386746 2007-09-19 11p15.5 MRGPRG MRGPRG gene 2007-09-19 2007-09-19 2007-09-19 Xq13-q21 GI:5030 P2RY4 P2RY4 gene P2RY4 gene Darc mRNA (NM 010045.1) Darc mRNA (NM 010045.1) RefSeq:NM 010045.1 2007-09-19 2007-09-19 DRD2 mRNA (NM 000795.2) 2007-09-19 DRD2 mRNA (NM 000795.2) RefSeq:NM 000795.2 2007-09-19 A2B A2B receptor A2B receptor 2007-09-19 IUPHAR:2.1:ADO:3:A2B: 2007-09-19 2007-09-19 Mc1r mRNA (NM 008559.1) Mc1r mRNA (NM 008559.1) 2007-09-19 RefSeq:NM 008559.1 2007-09-19 2007-09-19 Other Orphan Gene receptor - unspecified 27 2007-09-19 Other Orphan Gene receptor - unspecified 27 2007-09-19 Htr1f mRNA (NM 008310.2) 2007-09-19 RefSeq:NM 008310.2 2007-09-19 Htr1f mRNA (NM 008310.2) April 23, 2009 Autoreceptor A receptor located on a nerve terminal that is sensitive to the neurotransmitter released by that terminal. 2007-09-06 2007-09-06 Tetrameric Voltage-gated ion channel Tetrameric Voltage-gated ion channel Gpr68 gene GI:314386 Gpr68 gene 2007-09-19 Gpr68 6q32 2007-09-19 2007-09-19 FPR1 mRNA (NM 002029.3) RefSeq:NM 002029.3 2007-09-19 FPR1 mRNA (NM 002029.3) P2ry10 gene 2007-09-19 P2ry10 gene RGD1561912 P2ry10 2007-09-19 Xq31 GI:317219 Integrin Integrin C0021701 April 22, 2009 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Molecule.owl#sao1048879260 uncurated sao1846292151 P2Y receptor - unspecified 1 SP:Q9ESG6 2007-09-19 2007-09-19 P2Y receptor - unspecified 1 EBI2 GI:1880 EBI2 gene 2007-09-19 13q32.3 2007-09-19 EBI2 gene 2007-09-06 Cav3.2 minimum pore seqence Cav3.2 minimum pore seqence QVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM 2007-09-06 Orphan (Mas-related) receptor - unspecified 10 2007-09-19 SP:Q4V9L2 2007-09-19 Orphan (Mas-related) receptor - unspecified 10 2007-09-06 KCNMC1 gene 2007-09-06 KCNMC1 8p11.2 KCNMC1 gene BC028701 2007-09-06 2007-09-06 Human chromosome 16 Human chromosome 16 2007-09-19 2007-09-19 Other Orphan Gene receptor - unspecified 4 Other Orphan Gene receptor - unspecified 4 2007-09-19 BKR1 BRADYB1 B1R Bdkrb B1BKR Bdkrb1 gene Bdkrb1 12 F1 Bdkrb1 gene GI:12061 2007-09-19 2007-09-19 2007-09-19 SP:P51582 P2Y4 receptor P2Y4 receptor RefSeq:NM 005282.1 2007-09-19 GPR4 mRNA (NM 005282.1) 2007-09-19 GPR4 mRNA (NM 005282.1) A2B receptor 2007-09-19 A2B receptor 2007-09-19 SP:Q60614 2007-09-19 MC1 receptor 2007-09-19 MC1 receptor 5-HT1F receptor 5-HT1F receptor 2007-09-19 2007-09-19 SP:P30940 2007-09-19 2007-09-19 Alpha 3 Acetylcholine Receptor alpha 1 nicotinic sao99825125 NACHRA3 April 27, 2010 uncurated Neuronal Acetylcholine Receptor Subunit Alpha-3 Neuronal acetylcholine receptor subunit alpha-3 is encoded by the human CHRNA3 gene. This protein plays a role in ion transport. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. (Adapted from NCBI and Swiss-Prot). Alpha 3 Acetylcholine Receptor CHRNA3 Cholinergic receptor 2007-09-19 7p14-p15 2007-09-19 NPSR1 gene NPSR1 gene GI:387129 NPSR1 2007-09-19 11q23.2 2007-09-19 DRD2 gene DRD2 GI:1813 DRD2 gene P2Y4 P2Y4 receptor IUPHAR:2.1:NUCT:3:P2Y4: 2007-09-19 P2Y4 receptor 2007-09-19 P2ry14 mRNA (NM 133200.3) 2007-09-19 RefSeq:NM 133200.3 P2ry14 mRNA (NM 133200.3) 2007-09-19 2007-09-06 mtegaraadevrvplgapppgpaalvgaspespgapgreaergselgvspsespaaergaelgadeeqrvpypalaatvffclgqttrprswclrlvcnpwfehvsmlvimlncvtlgmfrpcedvecgsercnileafdafifaffavemvikmvalglfgqkcylgdtwnrldffivvagmmeysldghnvslsairtvrvlrplrainrvpsmrilvtllldtlpmlgnvlllcffvffifgivgvqlwagllrnrcfldsafvrnnnltflrpyyqteegeenpficssrrdngmqkcshipgrrelrmpctlgweaytqpqaegvgaarnacinwnqyynvcrsgdsnphngainfdnigyawiaifqvitlegwvdimyyvmdahsfynfiyfilliivgsffminlclvviatqfsetkqresqlmreqrarhlsndstlasfsepgscyeellkyvghifrkvkrrslrlyarwqsrwrkkvdpsavqgqgpghrqrragrhtasvhhlvyhhhhhhhhhyhfshgsprrpgpepgacdtrlvragappsppspgrgppdaesvhsiyhadchiegpqerarvahaaataaaslrlatglgtmnyptilpsgvgsgkgstspgpkgkwaggppgtgghgplslnspdpyekiphvvgehglgqapghlsglsvpcplpsppagtltcelkscpyctraledpegelsgsesgdsdgrgvyeftqdvrhgdrwdptrppratdtpgpgpgspqrraqqraapgepgwmgrlwvtfsgklrrivdskyfsrgimmailvntlsmgveyheqpeeltnaleisnivftsmfalemllkllacgplgyirnpynifdgiivvisvweivgqadgglsvlrtfrllrvlklvrflpalrrqlvvlvktmdnvatfctllmlfififsilgmhlfgckfslktdtgdtvpdrknfdsllwaivtvfqiltqedwnvvlyngmastsswaalyfvalmtfgnyvlfnllvailvegfqaegdanrsdtdedktsvhfeedfhklrelqttelkmcslavtpnghlegrgslspplimctaatpmptpksspfldaapslpdsrrgssssgdpplgdqkppaslrsspcapwgpsgawssrrsswsslgrapslkrrgqcgeresllsgegkgstddeaedgraapgpratplrraesldprplrpaalpptkcrdrdgqvvalpsdfflridshredaaeldddsedscclrlhkvlepykpqwcrsreawalylfspqnrfrvscqkvithkmfdhvvlvfiflncvtialerpdidpgstervflsvsnyiftaifvaemmvkvvalgllsgehaylqsswnlldgllvlvslvdivvamasaggakilgvlrvlrllrtlrplrvisrapglklvvetlisslrpignivliccaffiifgilgvqlfkgkfyycegpdtrnistkaqcraahyrwvrrkynfdnlgqalmslfvlsskdgwvnimydgldavgvdqqpvqnhnpwmllyfisfllivsffvlnmfvgvvvenfhkcrqhqeaeearrreekrlrrlerrrrstfpspeaqrrpyyadysptrrsihslctshyldlfitfiicvnvitmsmehynqpksldealkycnyvftivfvfeaalklvafgfrrffkdrwnqldlaivllslmgitleeiemsaalpinptiirimrvlriarvlkllkmatgmralldtvvqalpqvgnlgllfmllffiyaalgvelfgrlecsednpceglsrhatfsnfgmafltlfrvstgdnwngimkdtlrecsredkhclsylpalspvyfvtfvlvaqfvlvnvvvavlmkhleesnkearedaeldaeielemaqgpgsarrvdadrpplpqespgardapnlvarkvsvsrmlslpndsymfrpvvpasaphprplqevemetygagtplgsvasvhsppaescaslqiplavssparsgeplhalsprgtarspslsrllcrqeavhtdslegkidsprdtldpaepgektpvrpvtqggslqspprsprpasvrtrkhtfgqrcvssrpaapggeeaeasdpadeevshitssacpwqptaephgpeaspvaggerdlrrlysvdaqgfldkpgradeqwrpsaelgsgepgeakawgpeaepalgarrkkkmsppcisveppaedegsarpsaaeggsttlrrrtpsceatphrdsleptegsgaggdpaakgerwgqascraehltvpsfafepldlgvpsgdpfldgshsvtpesrasssgaivpleppeseppmpvgdppekrrglyltvpqcplekpgspsatpapgggaddpv Cav3.2 channel aa sequence 2007-09-06 Cav3.2 channel aa sequence 2007-09-19 Ebi2 GI:321019 14 E5 Ebi2 gene Ebi2 gene 2007-09-19 GI:2357 2007-09-19 2007-09-19 FPR1 FPR1 gene 19q13.4 FPR1 gene OrphanA13 receptor - unspecified 2 2007-09-19 OrphanA13 receptor - unspecified 2 2007-09-19 Receptor role April 24, 2009 GI:259249 2007-09-19 11p15.1 MRGPRX1 MRGPRX1 gene MRGPRX1 gene 2007-09-19 2007-09-06 2007-09-06 a1I T-type Cav3.2 Cav3.2 Kca5.1 minimum pore seqence Kca5.1 minimum pore seqence 2007-09-06 FSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMV 2007-09-06 Other Orphan Gene receptor - unspecified 4 Other Orphan Gene receptor - unspecified 4 2007-09-19 2007-09-19 SP:Q9Y2T6 2007-09-19 Bdkrb1 mRNA (NM 007539.2) Bdkrb1 mRNA (NM 007539.2) 2007-09-19 RefSeq:NM 007539.2 NPS receptor IUPHAR:2.1:NPS:1:NPS: NPS receptor 2007-09-19 2007-09-19 NPS RefSeq:NM 000676.2 ADORA2B mRNA (NM 000676.2) ADORA2B mRNA (NM 000676.2) 2007-09-19 2007-09-19 SPC/LPC receptor - unspecified 1 2007-09-19 SPC/LPC receptor - unspecified 1 SP:P46093 2007-09-19 Rat chromosome 11 Rat chromosome 11 2007-09-19 2007-09-19 GI:136 ADORA2B gene ADORA2B gene ADORA2B 2007-09-19 2007-09-19 17p12-p11.2 P2ry14 mRNA (NM 001008497.1) 2007-09-19 RefSeq:NM 001008497.1 2007-09-19 P2ry14 mRNA (NM 001008497.1) 2007-09-19 Adrb1 mRNA (NM 012701.1) Adrb1 mRNA (NM 012701.1) RefSeq:NM 012701.1 2007-09-19 SP:Q6W5P4 2007-09-19 2007-09-19 NPS receptor NPS receptor D2 receptor 2007-09-19 D2 receptor SP:P14416 2007-09-19 2007-09-06 2007-09-06 Voltage-gated sodium channel Voltage-gated sodium channel sodium channel Na+ channel Nav channel CMKLR1 mRNA (NM 004072.1) RefSeq:NM 004072.1 2007-09-19 2007-09-19 CMKLR1 mRNA (NM 004072.1) Other Orphan Gene receptor - unspecified 34 2007-09-19 2007-09-19 Other Orphan Gene receptor - unspecified 34 Synphilin-1 Sarah M. Maynard uncurated sao9423328013 Synphilin-1 A 919-amino-acid protein that interacts with alpha-synuclein. RefSeq:NM 172435.2 P2ry10 mRNA (NM 172435.2) 2007-09-19 P2ry10 mRNA (NM 172435.2) 2007-09-19 2007-09-19 RefSeq:XM 234483.3 2007-09-19 Gpr68 mRNA (XM 234483.3) Gpr68 mRNA (XM 234483.3) 2007-09-19 SP:P21462 N-formylpeptide receptor - unspecified 2 2007-09-19 N-formylpeptide receptor - unspecified 2 Enzyme April 22, 2009 sao956358115 A protein that speeds up chemical reactions in the body (PDQ). C0014442 2007-09-19 2007-09-19 MC1 receptor 2007-09-19 IUPHAR:2.1:MC:1:MC1: 2007-09-19 MC1 receptor MC1 Gpr4 Gpr4 gene 7 A3 GI:319197 2007-09-19 2007-09-19 Gpr4 gene RefSeq:XM 001057934.1 Fpr1 mRNA (XM 001057934.1) 2007-09-19 Fpr1 mRNA (XM 001057934.1) 2007-09-19 2007-09-06 NM 004978 1p21 KCNC4 gene KCNC4 KCNC4 gene 2007-09-06 2007-09-19 SP:Q9BZJ7 Other Orphan Gene receptor - unspecified 5 2007-09-19 Other Orphan Gene receptor - unspecified 5 2007-09-19 Bind a ligand 2007-09-19 Bind a ligand Wnt1 peptide 2007-09-19 Wnt1 peptide 2007-09-19 Slick Kca4.2 Synonyms added. 2007-09-06 2007-09-06 Maryann Martone December 17, 2008 Kca4.2 Slo2.1 Edg6 mRNA (NM 010102.1) 2007-09-19 Edg6 mRNA (NM 010102.1) 2007-09-19 RefSeq:NM 010102.1 Neurotrophin-3 NT-3 April 22, 2009 Anita Bandrowski Neurotrophin-3, or NT-3, is a neurotrophic factor, in the NGF-family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after NGF and BDNF. Although the vast majority of neurons in the mammalian brain are formed prenatally, parts of the adult brain retain the ability to grow new neurons from neural stem cells; a process known as neurogenesis. Neurotrophins are chemicals that help to stimulate and control neurogenesis. NT-3 is unique in the number of neurons it can potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB - see below). Mice born without the ability to make NT-3 have loss of proprioceptive and subsets of mechanoreceptive sensory neurons. 3p21.1-9 2007-09-19 GPR62 gene GI:118442 2007-09-19 GPR62 GPR62 gene 2007-09-19 Ptgdr GI:63889 Ptgdr gene Ptgdr gene Ptgdr2 2007-09-19 15p14 Kca4.1 channel aa sequence Kca4.1 channel aa sequence 2007-09-06 2007-09-06 mcnsvstctgkgarrgtlcflvfglqhlklgplptrlkvlcvpvwgnareegggshsllprvgselpgrmplpdgartpggvcreargggytnrtfefddgqcaprrpcagdgalldtagfkmsdldsevlplppryrfrdlllgdpsfqnddrvqvefyvnentfkerlklffiknqrsslrirlfnfslklltcllyivrvllddpalgigcwgcpkqnysfndssseinwapilwverkmtlwaiqvivaiisfletmlliylsykgniweqifrvsfvlemintlpfiitifwpplrnlfipvflncwlakhalenmindfhrailrtqsamfnqvlilfctllclvftgtcgiqhleragenlslltsfyfcivtfstvgygdvtpkiwpsqllvvimicvalvvlplqfeelvylwmerqksggnysrhraqtekhvvlcvsslkidllmdflnefyahprlqdyyvvilcptemdvqvrrvlqiplwsqrviylqgsalkdqdlmrakmdngeacfilssrnevdrtaadhqtilrawavkdfapncplyvqilkpenkfhvkfadhvvceeeckyamlalncicpatstlitllvhtsrgqegqespeqwqrmygrcsgnevyhirmgdskffreyegksftyaafhahkkygvcliglkrednksillnpgprhilaasdtcfyinitkeensafifkqeekrkkrafsgqglhegparlpvhsiiasmgtvamdlqgtehrptqsggggggsklalptengsgsrrpsiapvleladssallpcdllsdqsedevtpsddeglsvveyvkgyppnspyigssptlchllpvkapfcclrldkgckhnsyedakaygfknkliivsaetagnglynfivplrayyrsrkelnpivllldnkpdhhfleaiccfpmvyymegsvdnldsllqcgiiyadnlvvvdkestmsaeedymadaktivnvqtmfrlfpslsittelthpsnmrfmqfrakdsyslalsklekrerengsnlafmfrlpfaagrvfsismldtllyqsfvkdymititrlllgldttpgsgylcamkitegdlwirtygrlfqklcsssaeipigiyrteshvfstsephdlraqsqisvnvedcedtrevkgpwgsragtggssqgrhtgggdpaehpllrrkslqwarrlsrkapkqagraaaaewisqqrlslyrrserqelselvknrmkhlglpttgyedvanltasdvmnrvnlgylqgnsalagadhrttglanpsppaallrhpgqaggqel GI:78826 P2Y10 P2ry10 gene P2ry10 RP23-35H8.1 P2ry10 gene X D 5830408N17Rik 2007-09-19 2007-09-19 SP:O00155 2007-09-19 Other Orphan Gene receptor - unspecified 27 Other Orphan Gene receptor - unspecified 27 2007-09-19 2007-09-19 2007-09-19 P2ry14 gene P2ry14 MGC93098 P2ry14 gene Gpr105 GI:171108 2q31 2007-09-19 Hcrtr1 mRNA (NM 013064.1) Hcrtr1 mRNA (NM 013064.1) 2007-09-19 RefSeq:NM 013064.1 CMKLR1 GI:1240 12q24.1 2007-09-19 2007-09-19 CMKLR1 gene CMKLR1 gene MC1 receptor MC1 receptor 2007-09-19 2007-09-19 SP:Q01726 2007-09-06 Dimeric dimer ion channel Dimeric dimer ion channel 2007-09-06 Other Orphan Gene receptor - unspecified 17 2007-09-19 2007-09-19 Other Orphan Gene receptor - unspecified 17 SP:Q8BL07 sao1442185587 April 24, 2009 Extracellular Matrix Protein Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., collagen, elastin, fibronectins, and laminin). (MSH) http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Molecule.owl#sao26622963 C0079323 Extracellular Matrix Protein uncurated 2007-09-19 12q11 Gpr30 Gpr30 gene GPR41 Gpr30 gene 2007-09-19 GI:171104 Wnt peptide 2007-09-19 Wnt peptide 2007-09-19 2007-09-19 2007-09-19 3p22.2 CX3CR1 CX3CR1 gene CX3CR1 gene GI:1524 2007-09-19 2007-09-19 2007-09-19 RefSeq:NM 175668.2 Gpr4 mRNA (NM 175668.2) Gpr4 mRNA (NM 175668.2) 2007-09-19 Kv3.4 2007-09-06 Kv3.4 mKv3.4 2007-09-06 Raw3 HKShIIIC Monoamine Oxidase B Oxidase, Tyramine Type A Monoamine Oxidase MAO-B May 13, 2010 MAO MAO A Amine:oxygen oxidoreductase (deaminating) (flavin-containing) MAO MAO B Monoamine Oxidase MAO-A An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4. (from MSH) Monoamine Oxidase A Type B Monoamine Oxidase Amine Oxidase (Flavin-Containing) Tyramine Oxidase Oxidase, Monoamine 2007-09-19 2007-09-19 GI:292409 Fpr1 1q12 Fpr1 gene 2007-09-19 Fpr1 gene 2007-09-19 Novel Neurotrophin-1 (NNT-1) is also known as "B cell-stimulating factor-3" (BSF-3) or "cardiotrophin-like cytokine factor 1" (CLCF1), and is a cytokine belonging to the interleukin-6 family. It is a secreted protein, found predominantly in lymph nodes and spleen, which contains 225 amino acids with a molecular mass of 22 kDa in its mature form. It is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor. The term "neurotrophin" is commonly used to refer collectively to the four structurally related factors NGF, BDNF, NT-3 and NT-4, while NNT1 bears no structural resemblance to these four proteins. The terminology has become confusing since most scientists use the term "neurotrophin" to refer only to NGF, BDNF, NT-3 and NT-4, while a few scientists use the term "neurotrophin" to refer to any neurotrophic factor, of which there are many. CLCF-1 Cardiotrophin-like cytokine factor-1 Anita Bandrowski NNT-1 B cell-stimulating factor-3 Novel neurotrophin-1 April 22, 2009 BSF-3 2007-09-19 2007-09-19 CXCL15 CXCL15 1q31.3 2007-09-06 NM 198503 KCNT2 gene KCNT2 gene KCNT2 2007-09-06 Orphan (Mas-related) receptor - unspecified 10 2007-09-19 Proposed ligand, single publication 2007-09-19 Orphan (Mas-related) receptor - unspecified 10 Ptgdr mRNA (NM 022241.1) RefSeq:NM 022241.1 Ptgdr mRNA (NM 022241.1) 2007-09-19 2007-09-19 2007-09-19 2007-09-19 OrphanA13 receptor - unspecified 2 OrphanA13 receptor - unspecified 2 Mouse chromosome 13 Mouse chromosome 13 2007-09-19